By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Epithelial Cells. According to news originating from Morgantown, West Virginia, by NewsRx correspondents, research stated, "Multiwalled carbon nanotubes (MWCNT) are one of the most commonly produced nanomaterials, and pulmonary exposure during production, use, and disposal is a concern for the developing nanotechnology field. The airway epithelium is the first line of defense against inhaled particles."
Our news journalists obtained a quote from the research from National Institute for Occupational Safety and Health, "In a mouse model, MWCNT were reported to reach the alveolar space of the lung after in vivo exposure, penetrate the epithelial lining, and result in inflammation and progressive fibrosis. This study sought to determine the cellular and gene expression changes in small airway epithelial cells (SAEC) after in vitro exposure to MWCNT in an effort to elucidate potential toxicity mechanisms and signaling pathways. A direct interaction between SAEC and MWCNT was confirmed by both internalization of MWCNT and interaction at the cell periphery. Following exposure, SAEC showed time-dependent increases in reactive oxygen species production, total protein phosphotyrosine and phosphothreonine levels, and migratory behavior. Analysis of gene and protein expression suggested altered regulation of multiple biomarkers of lung damage, carcinogenesis, and tumor progression, as well as genes involved in related signaling pathways. These results demonstrate that MWCNT exposure resulted in the activation of SAEC."
According to the news editors, the research concluded: "Gene expression data derived from MWCNT exposure provide information that may be used to elucidate the underlying mode of action of MWCNT in the small airway and suggest potential prognostic gene signatures for risk assessment."
For more information on this research see: Systematic analysis of multiwalled carbon nanotube-induced cellular signaling and gene expression in human small airway epithelial cells. Review of Economic Dynamics, 2013;133(1):79-89. (Elsevier - www.elsevier.com; Review of Economic Dynamics - www.elsevier.com/wps/product/cws_home/622942)
The news correspondents report that additional information may be obtained from B.N. Snyder-Talkington, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, United States. Additional authors for this research include M. Pacurari, C. Dong, S.S. Leonard, D. Schwegler-Berry, V. Castranova, Y. Qian and N.L Guo (see also Epithelial Cells).
Keywords for this news article include: Morgantown, Fullerenes, West Virginia, United States, Nanotechnology, Epithelial Cells, Emerging Technologies, North and Central America, Multiwalled Carbon Nanotube.
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