By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Biotechnology have been published. According to news reporting originating in New York City, New York, by NewsRx journalists, research stated, "Diffuse optical tomography (DOT) is a noninvasive, nonionizing imaging modality that uses near-infrared light to visualize optically relevant chromophores. A recently developed dynamic DOT imaging system enables the study of hemodynamic effects in the breast during a breath-hold."
The news reporters obtained a quote from the research from Columbia University, "Dynamic DOT imaging was performed in a total of 21 subjects (age 54 +/- 10 years) including 3 healthy subjects and 18 subjects with benign (n = 8) and malignant (n = 14) masses. Three-dimensional time-series images of the percentage change in oxygenated and deoxygenated hemoglobin concentrations ([HbO(2)] and [Hb]) from baseline are obtained over the course of a breath-hold. At a time point of 15 s following the end of the breath-hold, [Hb] in healthy breasts has returned to near-baseline values (1.6% +/- 0.5%), while tumor-bearing breasts have increased levels of [Hb] (6.8% +/- 3.6%, p< 0.01). Further, healthy subjects have a higher correlation between the breasts over the course of the breath-hold as compared with the subjects with breast cancer (healthy: 0.96 +/- 0.02; benign: 0.89 +/- 0.02; malignant: 0.78 +/- 0.23, p< 0.05). Therefore this study shows that dynamic features extracted from DOT measurements can differentiate healthy and diseased breast tissues."
According to the news reporters, the research concluded: "These features provide a physiologic method for identifying breast cancer without the need for ionizing radiation."
For more information on this research see: Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography. Journal of Biomedical Optics, 2013;18(9):134-142. Journal of Biomedical Optics can be contacted at: Spie-Soc Photo-Optical Instrumentation Engineers, 1000 20TH St, PO Box 10, Bellingham, WA 98225, USA (see also technology.html">Biotechnology).
Our news correspondents report that additional information may be obtained by contacting M.L. Flexman, Columbia University, Dept. of Elect Engn, New York, NY 10027, United States. Additional authors for this research include H.K. Kim, J.E. Gunther, E.A. Lim, M.C. Alvarez, E. Desperito, K. Kalinsky, D.L. Hershman and A.H. Hielscher.
Keywords for this news article include: Biotechnology, Cancer, Oncology, New York City, United States, North and Central America
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