By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Current study results on Biotechnology have been published. According to news reporting from Guangzhou, People's Republic of China, by NewsRx journalists, research stated, "The bystander effect is an intriguing phenomenon by which adjacent cells become sensitized to drug treatment during gene therapy with herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV). This effect is reported to be mediated by gap junctional intercellular communication (GJIC), and therefore, we postulated that upregulation of genes that facilitate GJIC may enhance the HSV-tk/GCV bystander effect."
The news correspondents obtained a quote from the research from Guangzhou University, "Previous findings have shown Tanshinone IIA (Tan IIA), a chemical substance derived from a Chinese medicine herb, promotes the upregulation of the connexins Cx26 and Cx43 in B16 cells. Because gap junctions are formed by connexins, we hypothesized that Tan IIA might increase GJIC. Our results show that Tan IIA increased GJIC in B16 melanoma cells, leading to more efficient GCV-induced bystander killing in cells stably expressing HSV-tk. Additionally, in vivo experiments demonstrated that tumors in mice with 10% HSV-tk positive B16 cells and 90% wild-type B16 cells became smaller following treatment with the combination of GCV and Tan IIA as compared to GCV or Tan IIA alone."
According to the news reporters, the research concluded: "These data demonstrate that Tan IIA can augment the bystander effect of HSV-tk/GCV system through increased gap junction coupling, which adds strength to the promising strategy that develops connexins inducer to potentiate the effects of suicide gene therapy."
For more information on this research see: Tanshinone IIA increases the bystander effect of herpes simplex virus thymidine kinase/ganciclovir gene therapy via enhanced gap junctional intercellular communication. Plos One, 2013;8(7):e67662. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news journalists report that additional information may be obtained by contacting J. Xiao, Dept. of Biochemistry, Guangzhou University of Chinese Medicine, Guangzhou, People's Taiwan. Additional authors for this research include G. Zhang, P. Qiu, X. Liu, Y. Wu, B. Du, J. Li, J. Zhou, J. Li and Y. Tan (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Proteins, Virology, Guangzhou, Treatment, Proteomics, DNA Viruses, Gene Therapy, Bioengineering, Herpes Simplex, Thymidine Kinase, Viral Skin Diseases, DNA Virus Infections, Enzymes and Coenzymes, Herpesviridae Infections, People's Republic of China, Phosphotransferases (Alcohol Group Acceptor).
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