By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Optical Coherence Tomography. According to news originating from London, United Kingdom, by NewsRx correspondents, research stated, "To present a selected case series of different phenotypes of the normal outer plexiform layer (OPL) visualized by optical coherence tomography (OCT). Five cases were selected to represent the spectrum of appearances of the OPL in this case series."
Our news journalists obtained a quote from the research from University College London, "Categorical descriptions of each manifestation were then developed. Additional SD-OCT scans were obtained from a normal volunteer to further support the hypothesis. The inner one-third of the OPL typically appears hyperreflective on OCT, while the outer two-thirds (Henle fiber layer) may have a more varied appearance. Six different phenotypes of Henle fiber layer reflectivity were noted in this series, and classified as: bright, columnar, dentate, delimited, indistinct, and dark. The brightness of the Henle fiber layer appears to depend on the geometric angle between the OCT light beam and the axonal fibers in this portion of the OPL. This angle appears to be a function of the natural orientation of the Henle fiber layer tissue (theta(N)), the existence of subretinal pathology that alters the angle of the neurosensory retina (theta(P)), and the tilt angle of the tissue on the B-scan (theta(T)) due to decentered OCT acquisition. Since accurate interpretation of the OPL/ONL boundary is of vital importance to study the thickness of ONL, location of cystoid lesions, hyperreflective crescents over drusen, et al., our case series may aid better understanding of the OPL appearance in SD-OCT."
According to the news editors, the research concluded: "In the absence of clear delineation, it may be most correct to refer to indistinct OPL and ONL together as the photoreceptor nuclear axonal complex (PNAC)."
For more information on this research see: Different phenotypes of the appearance of the outer plexiform layer on optical coherence tomography. Graefes Archive for Clinical and Experimental Ophthalmology, 2013;251(10):2311-2317. Graefes Archive for Clinical and Experimental Ophthalmology can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA (see also Optical Coherence Tomography).
The news correspondents report that additional information may be obtained from Y.L. Ouyang, UCL Inst Ophthalmol, London, United Kingdom. Additional authors for this research include A.C. Walsh, P.A. Keane, F.M. Heussen, R.K.R. Pappuru and S.R. Sadda.
Keywords for this news article include: London, Europe, United Kingdom, Imaging Technology, Optical Coherence Tomography
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