By a News Reporter-Staff News Editor at Drug Week -- Current study results on Nanoparticles have been published. According to news reporting out of Bangkok, Thailand, by NewsRx editors, research stated, "Nano-formulation of poorly water-soluble drugs has been developed to enhance drug dissolution. In this review, we introduce nano-milling technology described in recently published papers."
Our news journalists obtained a quote from the research from Mahidol University, "Factors affecting the size of drug crystals are compared based on the preparation methods and drug and excipient types. A top-down approach using the comminution process is a method conventionally used to prepare crystalline drug nanoparticles. Wet milling using media is well studied and several wet-milled drug formulations are now on the market. Several trials on drug nanosuspension preparation using different apparatuses, materials, and conditions have been reported. Wet milling using a high-pressure homogenizer is another alternative to preparing production-scale drug nanosuspensions. Dry milling is a simple method of preparing a solid-state drug nano-formulation. The effect of size on the dissolution of a drug from nanoparticles is an area of fundamental research, but it is sometimes incorrectly evaluated. Here, we discuss evaluation procedures and the associated problems."
According to the news editors, the research concluded: "Lastly, the importance of quality control, process optimization, and physicochemical characterization are briefly discussed."
For more information on this research see: Nano-Sized Crystalline Drug Production by Milling Technology. Current Pharmaceutical Design, 2013;19(35):6246-6258. Current Pharmaceutical Design can be contacted at: Bentham Science Publ Ltd, Executive Ste Y-2, PO Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates. (Bentham Science Publishers - www.benthamscience.com; Current Pharmaceutical Design - www.benthamscience.com/cpd/index.htm)
Our news journalists report that additional information may be obtained by contacting K. Moribe, Mahidol University, Fac Pharm, Bangkok 10400, Thailand. Additional authors for this research include K. Ueda, W. Limwikrant, K. Higashi and K. Yamamoto (see also Nanoparticles).
Keywords for this news article include: Asia, Bangkok, Thailand, Nanotechnology, Emerging Technologies
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