By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Current study results on Biotechnology have been published. According to news reporting out of Jinan, People's Republic of China, by NewsRx editors, research stated, "Glioblastoma multiforme (GBM) is the most common and malignant glioma. Although there has been considerable progress in treatment strategies, the prognosis of many patients with GBM remains poor."
Our news journalists obtained a quote from the research from Shandong University, "In this work, polyethylenimine (PEI) and the VTWTPQAWFQWV (VTW) peptide were modified and synthesized into GBM-targeting nanoparticles. The transfection efficiency of U-87 (human glioblastoma) cells was evaluated using fluorescence microscopy and flow cytometry. Cell internalization was investigated to verify the nanoparticle delivery into the cytoplasm. Results showed that the methods of polymer conjugation and the amount of VTW peptide were important factors to polymer synthesis and transfection. The PEI-VTW20 nanoparticles increased the transfection efficiency significantly."
According to the news editors, the research concluded: "This report describes the use of VTW peptide-based PEI nanoparticles for intracellular gene delivery in a GBM cell-specific manner."
For more information on this research see: A peptide-mediated targeting gene delivery system for malignant glioma cells. International Journal of Nanomedicine, 2013;8():3631-3640. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also technology.html">Biotechnology).
Our news journalists report that additional information may be obtained by contacting C.W. Wang, Shandong University, Qilu Hosp, Chinese Minist Public Hlth, Jinan 250012, People's Republic of China. Additional authors for this research include L.P. Ning, H.W. Wang, Z.J. Lu, X.G. Li, X.Y. Fan, X.P. Wang and Y.G. Liu.
Keywords for this news article include: Asia, Biotechnology, Jinan, Glioma, Oncology, Peptides, Proteins, Proteomics, Gene Therapy, Nanoparticle, Bioengineering, Nanotechnology, Emerging Technologies, People's Republic of China
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC