By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Proteins. According to news originating from Guangzhou, People's Republic of China, by NewsRx correspondents, research stated, "Chitosan has numerous biomedical applications such as tissue engineering scaffolds, drug/gene delivery systems, hemostasis materials, antibacterial materials, wound dressing, etc. In any case, chitosan administered in vivo would positively or passively contact or enter blood tissue."
Our news journalists obtained a quote from the research from the University of Jinan, "In this situation, the interaction of chitosan with blood components is critical to determine the efficacy and safety of the polymer. In this study, the effect of chitosan with different molecular weight and its derivative carboxymethyl chitosan (CMC) on the structure and function of clotting-related proteins was studied. Specifically, the structural and conformational change of fibrinogen, an important clotting protein, was studied by using UV, fluorescence, and circular dichroism spectroscopy, respectively. Further, the impact of chitosan and CMC on the clotting function was evaluated with activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen time (FT), and thromboelastography (TEG) assays. These results showed that, chitosan and fibrinogen can form complex mainly by electrostatic attraction. As a result, the structure and conformation of fibrinogen are altered by chitosan and CMC. Additionally, the presence of chitosan and CMC has little impact on the values of APTT, PT and FT, but causes significant abnormality in the clotting process by changing TEG parameters."
According to the news editors, the research concluded: "These results provide important insight into the molecular basis for the biological response to chitosan and other biopolymers."
For more information on this research see: Effect of chitosan and carboxymethyl chitosan on fibrinogen structure and blood coagulation. Journal of Biomaterials Science Polymer Edition, 2013;24(13):1549-63 (see also Proteins).
The news correspondents report that additional information may be obtained from W. Zhang, Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Dept. of Biomedical Engineering , Jinan University, Guangzhou, 510632, People's Taiwan. Additional authors for this research include D. Zhong, Q. Liu, Y. Zhang, N. Li, Q. Wang, Z. Liu and W. Xue.
Keywords for this news article include: Asia, Guangzhou, Fibrinogen, Protein Precursors, Acute Phase Proteins, Blood Coagulation Factors, People's Republic of China.
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