By a News Reporter-Staff News Editor at Gene Therapy Weekly -- New research on Stem Cell Research is the subject of a report. According to news reporting originating from Pittsburgh, Pennsylvania, by NewsRx correspondents, research stated, "Muscle-derived stem cells (MDSCs) isolated from mouse skeletal muscle by a modified preplate technique exhibit long-term proliferation, high self-renewal, and multipotent differentiation capabilities in vitro. MDSCs retrovirally transduced to express bone morphogenetic proteins (BMPs) can differentiate into osteocytes and chondrocytes and enhance bone and articular cartilage repair in vivo, a feature that is not observed with nontransduced MDSCs."
Our news editors obtained a quote from the research from the University of Pittsburgh, "These results emphasize that MDSCs require prolonged exposure to BMPs to undergo osteogenic and chondrogenic differentiation. A sustained BMP protein delivery approach provides a viable and potentially more clinically translatable alternative to genetic manipulation of the cells. A unique growth factor delivery platform comprised of native heparin and a synthetic polycation, poly(ethylene argininylaspartate diglyceride) (PEAD), was used to bind, protect, and sustain the release of bone morphogenetic protein-2 (BMP2) in a temporally and spatially controlled manner. Prolonged exposure to BMP2 released by the PEAD:heparin delivery system promoted the differentiation of MDSCs to an osteogenic lineage in vitro and induced the formation of viable bone at an ectopic site in vivo."
According to the news editors, the research concluded: "This new strategy represents an alternative approach for bone repair mediated by MDSCs while bypassing the need for gene therapy."
For more information on this research see: Sustained release of bone morphogenetic protein 2 via coacervate improves the osteogenic potential of muscle-derived stem cells. Stem Cells Translational Medicine, 2013;2(9):667-77 (see also Stem Cell Research).
The news editors report that additional information may be obtained by contacting H. Li, Dept. of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, United States. Additional authors for this research include N.R. Johnson, A. Usas, A. Lu, M. Poddar, Y. Wang and J. Huard.
Keywords for this news article include: Biotechnology, Peptides, Pittsburgh, Pennsylvania, Gene Therapy, United States, Bone Research, Bioengineering, Stem Cell Research, North and Central America, Bone Morphogenetic Protein 2, TGF beta Superfamily Proteins.
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