By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Membrane Proteins are presented in a new report. According to news originating from Athens, Greece, by NewsRx correspondents, research stated, "Molecular recognition features (MoRFs) are small, intrinsically disordered regions in proteins that undergo a disorder-to-order transition on binding to their partners. MoRFs are involved in protein-protein interactions and may function as the initial step in molecular recognition."
Our news journalists obtained a quote from the research from the University of Athens, "The aim of this work was to collect, organize and store all membrane proteins that contain MoRFs. Membrane proteins constitute similar to 30% of fully sequenced proteomes and are responsible for a wide variety of cellular functions. MoRFs were classified according to their secondary structure, after interacting with their partners. We identified MoRFs in transmembrane and peripheral membrane proteins. The position of transmembrane protein MoRFs was determined in relation to a protein's topology. All information was stored in a publicly available mySQL database with a user-friendly web interface."
According to the news editors, the research concluded: "A Jmol applet is integrated for visualization of the structures. mpMoRFsDB provides valuable information related to disorder-based protein-protein interactions in membrane proteins."
For more information on this research see: mpMoRFsDB: a database of molecular recognition features in membrane proteins. Bioinformatics, 2013;29(19):2517-2518. Bioinformatics can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Bioinformatics - bioinformatics.oxfordjournals.org)
The news correspondents report that additional information may be obtained from F. Gypas, University of Athens, Dept. of Cell Biol & Biophys, Fac Biol, Athens 15701, Greece. Additional authors for this research include G.N. Tsaousis and S.J. Hamodrakas (see also Membrane Proteins).
Keywords for this news article include: Athens, Greece, Europe, Peptides, Amino Acids, Nanotechnology, Membrane Proteins, Emerging Technologies, Molecular Recognition
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