By a News Reporter-Staff News Editor at Biotech Business Week -- Data detailed on Life Science Research have been presented. According to news reporting originating in Barcelona, Spain, by NewsRx journalists, research stated, "We present GStream, a method that combines genome-wide SNP and CNV genotyping in the Illumina microarray platform with unprecedented accuracy. This new method outperforms previous well-established SNP genotyping software."
The news reporters obtained a quote from the research from Research Institute, "More importantly, the CNV calling algorithm of GStream dramatically improves the results obtained by previous state-of-the-art methods and yields an accuracy that is close to that obtained by purely CNV-oriented technologies like Comparative Genomic Hybridization (CGH). We demonstrate the superior performance of GStream using microarray data generated from HapMap samples. Using the reference CNV calls generated by the 1000 Genomes Project (1KGP) and well-known studies on whole genome CNV characterization based either on CGH or genotyping microarray technologies, we show that GStream can increase the number of reliably detected variants up to 25% compared to previously developed methods. Furthermore, the increased genome coverage provided by GStream allows the discovery of CNVs in close linkage disequilibrium with SNPs, previously associated with disease risk in published Genome-Wide Association Studies (GWAS). These results could provide important insights into the biological mechanism underlying the detected disease risk association."
According to the news reporters, the research concluded: "With GStream, large-scale GWAS will not only benefit from the combined genotyping of SNPs and CNVs at an unprecedented accuracy, but will also take advantage of the computational efficiency of the method."
For more information on this research see: GStream: improving SNP and CNV coverage on genome-wide association studies. Plos One, 2013;8(7):e68822. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news correspondents report that additional information may be obtained by contacting A. Alonso, Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain. Additional authors for this research include S. Marsal, R. Tortosa, O. Canela-Xandri and A. Julia (see also Life Science Research).
Keywords for this news article include: Spain, Europe, Barcelona, Technology, Life Science Research.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC