Our news journalists obtained a quote from the research from Helmholtz-Institute for Biomedical Engineering, "In this work, the interaction of these new particles with HepG2 cells was analyzed, which express scavenger receptors class B type I (SR-BI) and ASGP-R. To study the contribution of these receptors as potential mediators for cellular uptake, receptor-blocking experiments were performed with d-lactose, a ligand for ASGP-R, Fucoidan, a putative ligand for SR-BI, and a SR-BI blocking antibody. Labeling with Cy5-modified DNA ligands enabled us to monitor the particle uptake by confocal fluorescence microscopy and flow cytometry, in order to discriminate the two putative pathways by competitive binding studies. While SR-BI-antibody and d-lactose had no inhibiting effects on particle uptake Fucoidan led to a complete inhibition."
According to the news editors, the research concluded: "Thus, a receptor-mediated uptake by the two receptors studied could not be proven and therefore other uptake mechanisms have to be considered."
For more information on this research see: Cellular uptake of fluorophore-labeled glyco-DNA-gold nanoparticles.
Our news journalists report that additional information may be obtained by contacting
Keywords for this news article include: Antibodies, Aachen,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC
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