By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Oncology have been published. According to news reporting from Nanjing, People's Republic of China, by NewsRx journalists, research stated, "MicroRNAs (miRNAs) are key regulators of gene expression and perform critical roles in various biological processes. To investigate the functional roles of miRNAs in the prolactin receptor (PRLR) signaling pathway in breast cancer, we constructed two small RNA libraries from human breast cancer T-47D cells treated with or without prolactin (PRL)."
The news correspondents obtained a quote from the research from Nanjing Medical University, "The miRNA expression profiles were systematically screened using Solexa deep-sequencing technology. More than 40 miRNAs were significantly differentially expressed, from which 4 miRNAs were chosen for validation by stem-loop real-time PCR. In addition, 3 novel miRNAs were selected for verification by PCR. Furthermore, upstream miRNA target genes were predicted using different algorithms, GO and KEGG analyses revealed that these targets were highly related to the PRLR signaling pathway."
According to the news reporters, the research concluded: "This study provides a reference for elucidating the complex miRNA-mediated regulatory networks of PRL/PRLR signaling pathway that affect breast cancer tumorigenesis and progression."
For more information on this research see: Identification and characterization of microRNAs expressed in human breast cancer T-47D cells in response to prolactin treatment by Solexa deep-sequencing technology. Biochemical and Biophysical Research Communications, 2013;432(3):480-7. (Elsevier - www.elsevier.com; Biochemical and Biophysical Research Communications - www.elsevier.com/wps/product/cws_home/622790)
Our news journalists report that additional information may be obtained by contacting Q. Wei, Dept. of Biotechnology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, People's Taiwan. Additional authors for this research include W. He, J. Yao, L. Guo, Y. Lu and X. Cao (see also Oncology).
Keywords for this news article include: Asia, Nanjing, Genetics, Oncology, Prolactin, Treatment, Technology, Breast Cancer, Women's Health, Peptide Hormones, Pituitary Gonadotropins, People's Republic of China, Anterior Pituitary Hormones.
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