By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Nanoparticles have been presented. According to news originating from Los Angeles, California, by NewsRx correspondents, research stated, "Protein polymers are repetitive amino acid sequences that can assemble monodisperse nanoparticles with potential applications as cancer nanomedicines. Of the currently available molecular imaging methods, positron emission tomography (PET) is the most sensitive and quantitative; therefore, this work explores microPET imaging to track protein polymer nanoparticles over several days."
Our news journalists obtained a quote from the research from the University of Southern California, "To achieve reliable imaging, the polypeptides were modified by site-specific conjugation using a heterobifunctional sarcophagine chelator, AmBaSar, which was subsequently complexed with (64)Cu. AmBaSar/(64)Cu was selected because it can label particles in vivo over periods of days, which is consistent with the timescales required to follow long-circulating nanotherapeutics. Using an orthotopic model of breast cancer, we observed four elastin-like polypeptides (ELPs)-based protein polymers of varying molecular weight, amino acid sequence, and nanostructure. To analyze this data, we developed a six-compartment image-driven pharmacokinetic model capable of describing their distribution within individual subjects. Surprisingly, the assembly of an ELP block copolymer (78 kD) into nanoparticles (R(h)=37.5 nm) minimally influences pharmacokinetics or tumor accumulation compared to a free ELP of similar length (74 kD). Instead, ELP molecular weight is the most important factor controlling the fate of these polymers, whereby long ELPs (74 kD) have a heart activity half-life of 8.7 hours and short ELPs (37 kD) have a half-life of 2.1 hours."
According to the news editors, the research concluded: "These results suggest that ELP-based protein polymers may be a viable platform for the development of multifunctional therapeutic nanoparticles that can be imaged using clinical PET scanners."
For more information on this research see: Kinetic quantification of protein polymer nanoparticles using non-invasive imaging. Integrative Biology, 2013;5(1):183-94. (Royal Society of Chemistry - www.rsc.org/; Integrative Biology - pubs.rsc.org/en/journals/journalissues/ib)
The news correspondents report that additional information may be obtained from S.M. Janib, Dept. of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90033-9121, United States. Additional authors for this research include S. Liu, R. Park, M.K. Pastuszka, P. Shi, A.S. Moses, M.M. Orosco, Y.A. Lin, H. Cui, P.S. Conti, Z. Li and J.A MacKay (see also Nanoparticles).
Keywords for this news article include: California, Los Angeles, United States, Nanotechnology, Emerging Technologies, North and Central America.
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