By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Nano and Microscale Research. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Quantum dots (QDs) have attracted great attention because of their favorable optical properties and have been widely applied in biomedical fields. However, in recent years, there have been an increasing number of reports about the cytotoxicity of QDs, especially cadmium-containing QDs, which may release cadmium ions to induce cytotoxicity."
The news correspondents obtained a quote from the research from the National Center for Nanoscience and Technology of China, "Importantly, the chemical composition and surface modifications of cadmium-based QDs determine the amount of Cd(2+) released inside the cell. Thus, there is an urgent need for more systematic work to study the relationship between cytotoxicity and the surface properties of QDs. In this article, the cytotoxicity of seven cadmium-containing QDs with different constituent elements and surface chemistries are compared. The results show that the cytotoxicity of QDs is closely related to their constituent elements and surface properties: First, CdTe@ZnS core-shell QDs show much lower cytotoxicity than naked ones when they have similar surface modifications; second, the positively charged QDs are more toxic than the negatively charged ones. Moreover, both positively and negatively charged QDs without ZnS coatings lead to multipolar spindles, misaligned chromosomes, and G2/M checkpoint failures. Interestingly, although CdSe QDs with a PEG coating cause no apparent cytotoxicity in any of the cell lines studied, they can localize near the contractile ring during cytokinesis and then block contractile ring disassembly. The cellular effect of CdTe QDs comes not only from the release of cadmium ions but also the intracellular distribution of QD nanoparticles in cells and the associated nanoscale effects. It is also found that QD-caused cytokinesis failure is closely related to the decreased expression of Cyclin A and Cyclin B. Taken together, the above findings provide new insight into the dynamic fate of QDs during cell mitosis, and are important for understanding the intracellular effects of QDs on the mitotic spindle and chromosomes during cell division."
According to the news reporters, the research concluded: "Furthermore, this kind of cytotoxicity evaluation method should be applicable to studies of the biological effects and health impacts of other nanomaterials."
For more information on this research see: The influence on cell cycle and cell division by various cadmium-containing quantum dots. Small, 2013;9(14):2440-51. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)
Our news journalists report that additional information may be obtained by contacting Y. Liu, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, People's Taiwan. Additional authors for this research include P. Wang, Y. Wang, Z. Zhu, F. Lao, X. Liu, W. Cong, C. Chen, Y. Gao and Y. Liu (see also Nano and Microscale Research).
Keywords for this news article include: Asia, Beijing, Cadmium, Quantum Dots, Quantum Physics, Transition Elements, People's Republic of China, Nano and Microscale Research.
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