By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Fresh data on Stem Cell Research are presented in a new report. According to news reporting out of Jerusalem, Israel, by NewsRx editors, research stated, "Bone regeneration achieved using mesenchymal stem cells (MSCs) and nonviral gene therapy holds great promise for patients with fractures seemingly unable to heal. Previously, MSCs overexpressing bone morphogenetic proteins (BMPs) were shown to differentiate into the osteogenic lineage and induce bone formation."
Our news journalists obtained a quote from the research from Hebrew University, "In the present study, we evaluated the potential of osteogenic differentiation in porcine adipose tissue-and bone marrow-derived MSCs (ASCs and BMSCs, respectively) in vitro and in vivo when induced by nucleofection with rhBMP-2 or rhBMP-6. Our assessment of the in vivo efficiency of this procedure was made using quantitative micro-computed tomography (micro-CT). Nucleofection efficiency and cell viability were similar in both cell types; however, the micro-CT analyses demonstrated that in both ASCs and BMSCs, nucleofection with rhBMP-6 generated bone tissue faster and of higher volumes than nucleofection with rhBMP-2. RhBMP-6 induced more efficient osteogenic differentiation in vitro in BMSCs, and in fact, greater osteogenic potential was identified in BMSCs both in vitro and in vivo than in ASCs."
According to the news editors, the research concluded: "On the basis of our findings, we conclude that BMSCs nucleofected with rhBMP-6 are superior at inducing bone formation in vivo than all other groups studied."
For more information on this research see: BMP-6 is more efficient in bone formation than BMP-2 when overexpressed in mesenchymal stem cells. Gene Therapy, 2013;20(4):370-7. (Nature Publishing Group - www.nature.com/; Gene Therapy - www.nature.com/gt/)
Our news journalists report that additional information may be obtained by contacting O. Mizrahi, Skeletal Biotech Laboratory, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem, Israel. Additional authors for this research include D. Sheyn, W. Tawackoli, I. Kallai, A. Oh, S. Su, X. Da, P. Zarrini, G. Cook-Wiens, D. Gazit and Z. Gazit (see also Stem Cell Research).
Keywords for this news article include: Asia, Biotechnology, Israel, Jerusalem, Gene Therapy, Bone Research, Bioengineering, Stem Cell Research, Mesenchymal Stem Cells.
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