By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Nanomedicine have been presented. According to news originating from Jiangsu, People's Republic of China, by NewsRx correspondents, research stated, "We prepared and studied novel fluorescent nanocomposites based on gambogic acid (GA) and cadmium-tellurium (CdTe) quantum dots (CdTe QDs) modified with cysteamine for purpose of cancer cell labeling and combined treatment. The nanocomposites were denoted as GA-CdTe."
Our news journalists obtained a quote from the research from Southeast University, "Characterization results indicated that the CdTe QDs can readily bind onto cell plasma membranes and then be internalized into cancer cells for real-time labeling and tracing of human liver hepatocellular carcinoma cell line (HepG2) cells. GA-CdTe significantly enhanced drug accumulation in HepG2 cells and inhibited cancer cell proliferation. GA-CdTe nanocomposites also improved the drug action of GA molecules in HepG2 cells and induced the G(2)/M phase arrest of the cancer cell cycle, promoting cell apoptosis. Given the sensitive, pH-triggered release of GA-CdTe, the side effects of GA anticancer agents on normal cells/tissues in the blood circulation markedly decreased. Efficient drug release and accumulation in target tumor cells were also facilitated."
According to the news editors, the research concluded: "Thus, the fluorescent GA-CdTe offered a new strategy for potential multimode cancer therapy and provided new channels for research into naturally-active compounds extracted from traditional Chinese medicinal plants."
For more information on this research see: Synergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition. International Journal of Nanomedicine, 2013;8():3729-3736. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Nanomedicine).
The news correspondents report that additional information may be obtained from P.P. Xu, Southeast Univ, Chien Shiung Wu Lab, State Key Lab Bioelect, Nanjing, Jiangsu, People's Republic of China. Additional authors for this research include J.Y. Li, L.X. Shi, M. Selke, B.A. Chen and X.M. Wang.
Keywords for this news article include: Asia, Cancer, Jiangsu, Cadmium, Oncology, Nanomedicine, Quantum Dots, Quantum Physics, Transition Elements, People's Republic of China
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