By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Epithelial Cells. According to news reporting from Dallas, Texas, by NewsRx journalists, research stated, "Endothelial cell (EC) activation and inflammation is a key step in the initiation and progression of many cardiovascular diseases. Targeted delivery of therapeutic reagents to inflamed EC using nanoparticles is challenging as nanoparticles do not arrest on EC efficiently under high shear stress."
The news correspondents obtained a quote from the research from the University of Texas Southwestern Medical Center, "In this study, we developed a novel polymeric platelet-mimicking nanoparticle for strong particle adhesion onto ECs and enhanced particle internalization by ECs. This nanoparticle was encapsulated with dexamethasone as the anti-inflammatory drug, and conjugated with polyethylene glycol, glycoprotein 1b, and trans-activating transcriptional peptide. The multi-ligand nanoparticle showed significantly greater adhesion on P-selectin, von Willebrand Factor, than the unmodified particles, and activated EC in vitro under both static and flow conditions. Treatment of injured rat carotid arteries with these multi-ligand nanoparticles suppressed neointimal stenosis more than unconjugated nanoparticles did."
According to the news reporters, the research concluded: "These results indicate that this novel multi-ligand nanoparticle is efficient to target inflamed EC and inhibit inflammation and subsequent stenosis."
For more information on this research see: Multi-ligand poly(L-lactic-co-glycolic acid) nanoparticles inhibit activation of endothelial cells. Journal of Cardiovascular Translational Research, 2013;6(4):570-8. Journal of Cardiovascular Translational Research can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Journal of Cardiovascular Translational Research - www.springerlink.com/content/1937-5387/)
Our news journalists report that additional information may be obtained by contacting H. Xu, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, United States. Additional authors for this research include S. Kona, L.C. Su, Y.T. Tsai, J.F. Dong, E.S. Brilakis, L. Tang, S. Banerjee and K.T Nguyen (see also Epithelial Cells).
Publisher contact information for the Journal of Cardiovascular Translational Research is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Texas, Dallas, Nanoparticle, United States, Nanotechnology, Epithelial Cells, Endothelial Cells, Emerging Technologies, North and Central America.
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