By a News Reporter-Staff News Editor at Cancer Weekly -- Researchers detail new data in Miniaturization. According to news reporting from Chongqing, People's Republic of China, by NewsRx journalists, research stated, "Circulating tumor cells (CTCs) are shed by primary tumours and are found in the peripheral blood of patients with metastatic cancers. Recent studies have shown that the number of CTCs corresponds with disease severity and prognosis."
The news correspondents obtained a quote from the research from Southwest University, "Therefore, detection and further functional analysis of CTCs are important for biomedical science, early diagnosis of cancer metastasis and tracking treatment efficacy in cancer patients, especially in point-of-care applications. Over the last few years, there has been an increasing shift towards not only capturing and detecting these rare cells, but also ensuring their viability for post-processing, such as cell culture and genetic analysis. High throughput lab-on-a-chip (LOC) has been fuelled up to process and analyse heterogeneous real patient samples while gaining profound insights for cancer biology. In this review, we highlight how miniaturisation strategies together with nanotechnologies have been used to advance LOC for capturing, separating, enriching and detecting different CTCs efficiently, while meeting the challenges of cell viability, high throughput multiplex or single-cell detection and post-processing. We begin this survey with an introduction to CTC biology, followed by description of the use of various materials, microstructures and nanostructures for design of LOC to achieve miniaturisation, as well as how various CTC capture or separation strategies can enhance cell capture and enrichment efficiencies, purity and viability. The significant progress of various nanotechnologies-based detection techniques to achieve high sensitivities and low detection limits for viable CTCs and/or to enable CTC post-processing are presented and the fundamental insights are also discussed."
According to the news reporters, the research concluded: "Finally, the challenges and perspectives of the technologies are enumerated."
For more information on this research see: Advances of lab-on-a-chip in isolation, detection and post-processing of circulating tumour cells. Lab On a Chip - Miniaturisation for Chemistry and Biology, 2013;13(16):3163-82 (see also Miniaturization).
Our news journalists report that additional information may be obtained by contacting L. Yu, Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, People's Taiwan. Additional authors for this research include S.R. Ng, Y. Xu, H. Dong, Y.J. Wang and C.M Li.
Keywords for this news article include: Asia, Cancer, Genetics, Oncology, Chongqing, Miniaturization, People's Republic of China.
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