By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Proteins are discussed in a new report. According to news originating from Hefei, People's Republic of China, by NewsRx correspondents, research stated, "Silica nanoparticles (SiNPs) are now in daily use due to their low intrinsic toxicity. Cadmium is a ubiquitous environmental pollutant."
Our news journalists obtained a quote from the research from the China University of Science and Technology, "In spite of real risk of humans' co-exposure to SiNPs and cadmium, their synergistic toxicity is still unclear. Here, we report the synergistic effects of SiNPs and CdCl2 on their biodistribution and subacute toxicity in mice. The biodistributions, histopathological changes, serum biochemical parameters and oxidative stress responses were determined after intraperitoneal injection of SiNPs and/or CdCl2 to mice. SiNPs and CdCl2 have a positive synergistic toxicity in mice. Although SiNPs were low toxic to mice, co-exposure of SiNPs and CdCl2 significantly enhanced CdCl2-induced oxidative damage in the liver as indicated by the severe liver dysfunction and histopathological abnormalities. Co-exposure to SiNPs and CdCl2 markedly increased the cadmium accumulation in the liver, which induced significant hepatic oxidative stress. In vitro binding assays indicated that serum albumin and Cd2+ mutually enhanced the binding of each other to SiNPs via the interaction of serum albumin and Cd2+. The uptake of serum albumin- and Cd2+-bound SiNPs by the macrophages significantly increased cadmium accumulation in mice."
According to the news editors, the research concluded: "These results demonstrate that serum albumins play an important role in the positive synergistic toxicity of SiNPs and CdCl2."
For more information on this research see: In vivo biodistribution and synergistic toxicity of silica nanoparticles and cadmium chloride in mice. Journal of Hazardous Materials, 2013;260():780-788. Journal of Hazardous Materials can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Hazardous Materials - www.elsevier.com/wps/product/cws_home/502691)
The news correspondents report that additional information may be obtained from M.C. Guo, China University of Science & Technology, Dept. of Chem, Hefei 230026, People's Republic of China. Additional authors for this research include X.L. Xu, X.C. Yan, S.S. Wang, S. Gao and S.S. Zhu (see also Proteins).
Keywords for this news article include: Asia, Hefei, Anions, Chemicals, Chemistry, Nanoparticle, Serum Albumin, Blood Proteins, Nanotechnology, Cadmium Chloride, Cadmium Compounds, Hydrochloric Acid, Transition Elements, Acute-Phase Proteins, Emerging Technologies, People's Republic of China
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