By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news reporting from Tamil Nadu, India, by NewsRx journalists, research stated, "Raman spectroscopy is a vibrational spectroscopic technique that can be used to optically probe the biomolecular changes associated with tumor progression. The aim of the present study is to investigate the biomolecular changes in chemopreventive response of prepared naringenin-loaded nanoparticles (NARNPs) relative to efficacy of free naringenin (NAR) during 7,12-dimethyl benz(a)anthracene (DMBA)-induced oral carcinogenesis by Fourier Transform Raman (FT-Raman) spectroscopy."
The news correspondents obtained a quote from the research from Annamalai University, "Oral squamous cell carcinoma (OSCC) was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Raman spectra differed significantly between the control and tumor tissues, with tumors showing higher percentage signals for nucleic acids, phenylalanine and tryptophan and a lower in the percentage of phospholipids. Moreover, oral administration of free NAR and NARNPs significantly increased phospholipids and decreased the levels of tryptophan, phenylalanine and nucleic acid contents. On a comparative basis, NARNPs was found to have a more potent antitumor effect than free NAR in completely preventing the formation of squamous cell carcinoma and in improving the biochemical status to a normal range in DMBA-induced oral carcinogenesis."
According to the news reporters, the research concluded: "The present study further suggest that Raman spectroscopy could be a valuable tool for rapid and sensitive detection of specific biomolecular changes in response to chemopreventive agents."
For more information on this research see: Raman spectroscopic investigation of the chemopreventive response of naringenin and its nanoparticles in DMBA-induced oral carcinogenesis. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 2013;115():648-653. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England (see also Nanoparticles).
Our news journalists report that additional information may be obtained by contacting N. Krishnakumar, Annamalai Univ, DDE, Annamalainagar 608002, Tamil Nadu, India. Additional authors for this research include N.K. Sulfikkarali, S. Manoharan and P. Venkatachalam.
Keywords for this news article include: Asia, India, Tamil Nadu, Nanotechnology, Emerging Technologies
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