Complete Final Analysis Demonstrated Promising Anti-tumor Activity
Data Presented at 2013 AACR-NCI-EORTC Molecular Targets and Cancer
Therapeutics Conference Supports Advancing ANG1005 into
Angiochem presented the Phase 2 ITT analysis with ANG1005 in 80 HER2-positive and HER2-negative breast cancer patients with brain metastases. Two doses, 650mg/m2 (n=13) and 550mg/m2 (n=67), were evaluated for intracranial anti-tumor responses including response rate, progression-free survival (PFS) and overall survival (OS) as well as safety and tolerability.
In the study, ANG1005 was generally safe and well-tolerated, and demonstrated an adverse event profile consistent with conventional taxane therapy in both HER2-positive and HER2-negative cohorts at both dose levels studied. In addition, patients in both the HER2-positive and HER2-negative populations experienced anti-tumor responses including up to 14 patients with intracranial partial responses (PR), 35 patients with stable disease (SD) and six months overall survival in up to 85%.
“Based on these encouraging results, we are excited to advance ANG1005 into further clinical development,” said
In a poster presentation entitled “A phase II study of ANG1005, a novel, brain-penetrant taxane derivative, in breast cancer patients with brain metastases,”
Based on these results, Angiochem will advance ANG1005 into further clinical development including a Phase 2 clinical study in patients with recurrent high grade gliomas which began enrolling in
ANG1005 is a novel paclitaxel-peptide drug conjugate that represents the first oncology product to leverage the (LRP-1) pathway to cross the blood-brain barrier (BBB) and enter cancer cells. ANG1005 has been studied in over 200 patients in three clinical studies; two phase 1 studies where the product has shown tolerability similar to paclitaxel and indications of activity, and a Phase 2 study for which the intent-to-treat (ITT) analysis demonstrated encouraging signs of anti-tumor activity and was reported at the 2013
Angiochem is a clinical-stage biotechnology company discovering and developing new breakthrough peptide drug conjugates that leverage the LRP-1 mediated pathway to cross the BBB to treat neurological diseases. These new compounds have the potential to address significant medical needs, many of which are insurmountable due to the fundamental physiological challenge posed by the BBB.
Angiochem is developing a focused product pipeline, including small molecules and biologics, for the potential treatment of a wide range of CNS diseases, including primary brain cancer, brain metastases, lysosomal storage diseases and pain. Founded in 2003, Angiochem maintains headquarters in
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