By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- New research on Biotechnology is the subject of a report. According to news reporting originating in Taipei, Taiwan, by NewsRx journalists, research stated, "Physiologic iodide-uptake, mediated by the sodium/iodide symporter (NIS), in the salivary gland confers its susceptibility to radioactive iodine-induced damage following I-131 treatment of thyroid cancer. Subsequent quality of life for thyroid cancer survivors can be decreased due to recurrent sialoadenitis and persistent xerostomia."
The news reporters obtained a quote from the research from Tri-Service General Hospital, "NIS expression at the three principal salivary duct components in various pathological conditions was examined to better our understanding of NIS modulation in the salivary gland. NIS expression was evaluated by immunohistochemistry in human salivary gland tissue microarrays constructed of normal, inflamed, and neoplastic salivary tissue cores. Cumulative I-123 radioactivity reflecting the combination of NIS activity with clearance of saliva secretion in submandibular and parotid salivary glands was evaluated by single-photon emission computed tomography/computed tomography imaging 24 hours after I-123 administration in 50 thyroid cancer patients. NIS is highly expressed in the basolateral membranes of the majority of striated ducts, yet weakly expressed in few intercalated and excretory duct cells. The ratio of I-123 accumulation between parotid and submandibular glands is 2.38 +/- 0.19. However, the corresponding ratio of I-123 accumulation normalized by volume of interest is 1.19 +/- 0.06. The percentage of NIS-positive striated duct cells in submandibular salivary glands was statistically greater than in parotid salivary glands, suggesting a higher clearance rate of saliva secretion in submandibular salivary glands. NIS expression in striated ducts was heterogeneously decreased or absent in sialoadenitis. Most ductal salivary gland tumors did not express NIS. However, Warthin's tumors of striated duct origin exhibited consistent and intense NIS staining, corresponding with radioactive iodine uptake. NIS expression is tightly modulated during the transition of intercalated to striated ducts and striated to excretory ducts in salivary ductal cells. NIS expression in salivary glands is decreased during inflammation and tumor formation."
According to the news reporters, the research concluded: "Further investigation may identify molecular targets and/or pharmacologic agents that allow selective inhibition of NIS expression/activity in salivary glands during radioactive iodine treatment."
For more information on this research see: Modulation of Sodium/Iodide Symporter Expression in the Salivary Gland. Thyroid, 2013;23(8):1029-1036. Thyroid can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA. (Mary Ann Liebert, Inc. - www.liebertpub.com; Thyroid - www.liebertpub.com/overview/thyroid/55/)
Our news correspondents report that additional information may be obtained by contacting K.M.D. La Perle, Tri-Service General Hospital, Natl Def Med Center, Dept. of Nucl Med, Taipei, Taiwan. Additional authors for this research include D.C. Kim, N.C. Hall, A. Bobbey, D.H. Shen, R.S. Nagy, P.E. Wakely, A. Lehman, D. Jarjoura and S.M. Jhiang (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Taipei, Taiwan, Iodine, Halogens, Oncology, Chemicals, Chemistry, Treatment, Sodium Iodide, Thyroid Cancer, Sodium Compounds, Thyroid Neoplasms, Cancer Gene Therapy
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC