By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Oncology have been presented. According to news reporting from Chicago, Illinois, by NewsRx journalists, research stated, "Photothermal ablation is a minimally invasive approach, which typically involves delivery of photothermal sensitizers to targeted tissues. The purpose of our study was to demonstrate that gold nanoparticles are phagocytosed by pancreatic cancer cells, thus permitting magnetic resonance imaging (MRI) of sensitizer delivery and photothermal ablation."
The news correspondents obtained a quote from the research from Robert H. Lurie Comprehensive Cancer Center, "Iron-oxide core/gold-shell nanoparticles (GoldMagŪ, 30 nm diameter; Xi'an GoldMag Biotechnology Co, Xi'an, People's Republic of China) were used. In a 96-well plate, 3 x 10(4) PANC-1 (human pancreatic cancer cell line) cells were placed. GoldMag (0, 25, or 50 mu g/mL) was added to each well and 24 hours allowed for cellular uptake. Samples were then divided into two groups: one treated with photothermal ablation (7.9 W/cm(2)) for 5 minutes, the other not treated. Photothermal ablation was performed using laser system (BWF5; B&W Tek, Inc, Newark, DE, USA). Intraprocedural temperature changes were measured using a fiber optic temperature probe (FTP-LN2; Photon Control Inc, Burnaby, BC, Canada). After 24 hours, the remaining number of viable cells was counted using trypan blue staining; cell proliferation percentage was calculated based on the total number of viable cells after treatment compared with control. MRI of GoldMag uptake was performed using a 7.0T ClinScan system (Bruker BioSpin, Ettlingen, Germany). Temperature curves demonstrated that with increased GoldMag uptake, laser irradiation produced higher temperature elevations in the corresponding samples; temperature elevations of 12.89 degrees C, 35.16 degrees C, and 79.51 degrees C were achieved for 0, 25, and 50 mu g/mL GoldMag. Without photothermal ablation, the cell proliferation percentage changed from 100% to 71.3% and 47.0% for cells treated with 25 and 50 mu g/mL GoldMag. Photothermal ablation of PANC-1 cells demonstrated an effective treatment response, specifically a reduction to only 61%, 21.9%, and 2.3% cell proliferation for cells treated with 0, 25, and 50 mu g/mL GoldMag. MRI was able to visualize GoldMag uptake within PANC-1 cells. Our findings suggest that photothermal ablation may be effective in the treatment of pancreatic cancer."
According to the news reporters, the research concluded: "GoldMag nanoparticles could serve as photothermal sensitizers, and MRI is feasible to quantify delivery."
For more information on this research see: Photothermal ablation of pancreatic cancer cells with hybrid iron-oxide core gold-shell nanoparticles. International Journal of Nanomedicine, 2013;8():3437-3446. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Oncology).
Our news journalists report that additional information may be obtained by contacting Y. Guo, Robert H Lurie Comprehens Canc Center, Chicago, IL, United States. Additional authors for this research include Z.L. Zhang, D.H. Kim, W.G. Li, J. Nicolai, D. Procissi, Y. Huan, G.H. Han, R.A. Omary and A.C. Larson.
Keywords for this news article include: Chicago, Illinois, Oncology, Treatment, Nanoparticle, United States, Nanotechnology, Gastroenterology, Pancreatic Cancer, Cell Proliferation, Pancreatic Neoplasms, Emerging Technologies, North and Central America
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