By a News Reporter-Staff News Editor at Journal of Technology -- New research on Materials Science is the subject of a report. According to news reporting originating from Cincinnati, Ohio, by VerticalNews correspondents, research stated, "A novel dual drug delivery system is presented using triaxial structured nanofibers, which provides different release profiles for model drugs separately loaded in either the sheath or the core of the fiber. Homogenous, coaxial and triaxial fibers containing a combination of materials (PCL, polycaprolactone; PVP, polyvinylpyrrolidone) were fabricated."
Our news editors obtained a quote from the research from the University of Cincinnati, "The drug release profiles were simulated using two color dyes (KAB, keyacid blue; KAU, keyacid uranine), whose release in physiological solution was measured using optical absorption as a function of time. To reach the level of 80% release of encapsulated dye from core, triaxial fibers with a PCL intermediate layer exhibited a similar to 24x slower release than that from coaxial fibers. At the same time, the hygroscopic sheath layer of the triaxial fibers provided an initial burst release (similar to 80% within an hour) of a second dye as high as that from conventional single and coaxial fibers. The triaxial fiber membrane provides both a quick release from the outer sheath layer for short-term treatment and a sustained release from the fiber core for long-term treatment. The intermediate layer between inner core and outer sheath acts as a barrier to prevent leaching from the core, which can be especially important when the membranes are used in wet application."
According to the news editors, the research concluded: "The formation of tri/multiaxially electrospun nanofibrous membranes will be greatly beneficial for biomedical applications by enabling different release profiles of two different drugs from a membrane."
For more information on this research see: Triaxial Electrospun Nanofiber Membranes for Controlled Dual Release of Functional Molecules. ACS Applied Materials & Interfaces, 2013;5(16):8241-8245. ACS Applied Materials & Interfaces can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
The news editors report that additional information may be obtained by contacting D. Han, University of Cincinnati, Nanoelect Lab, Cincinnati, OH 45221, United States.
Keywords for this news article include: Ohio, Treatment, Cincinnati, United States, Materials Science, North and Central America
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