By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Essential Amino Acids have been presented. According to news originating from Rome, Italy, by NewsRx correspondents, research stated, "Biocompatible molecules that undergo self-assembly are of high importance in biological and medical applications of nanoscience. Peptides and bile acids are among the most investigated due to their ability to self-organize into many different, often stimuli-sensitive, supramolecular structures."
Our news journalists obtained a quote from the research from Sapienza University, "With the aim of preparing molecules mixing the aggregation properties of bile acid and amino acid-based molecules, we report on the synthesis and self-association behavior of two diastereomers obtained by substituting a hydroxyl group of cholic acid with a L-phenylalanine residue. The obtained molecules are amphoteric, and we demonstrate that they show a pH-dependent self-assembly. Both molecules aggregate in globular micelles at high pH, whereas they form tubular superstructures under acid conditions. Unusual narrow nanotubes with outer and inner cross-section diameters of about 6 and 3 um are formed by the derivatives. The diasteroisomer with alpha orientation of the substituent forms in addition a wider tubule (17 nm cross-section diameter). The ability to pack in supramolecular tubules is explained in terms of a wedge-shaped bola-form structure of the derivatives."
According to the news editors, the research concluded: "Parallel or antiparallel face-to-face dimers are hypothesized as fundamental building blocks for the formation of the narrow and wide nanotubes, respectively."
For more information on this research see: Between Peptides and Bile Acids: Self-Assembly of Phenylalanine Substituted Cholic Acids. Journal of Physical Chemistry B, 2013;117(31):9248-9257. Journal of Physical Chemistry B can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Physical Chemistry B - www.pubs.acs.org/journal/jpcbfk)
The news correspondents report that additional information may be obtained from L. Travaglini, Roma La Sapienza University, CNISM, I-00185 Rome, Italy. Additional authors for this research include A. D'Annibale, M.C. di Gregorio, K. Schillen, U. Olsson, S. Sennato, N.V. Pavel and L. Galantini (see also Essential Amino Acids).
Keywords for this news article include: Rome, Italy, Europe, Nanotube, Peptides, Proteins, Proteomics, Phenylalanine, Nanotechnology, Supramolecular, Aromatic Amino Acids, Emerging Technologies, Essential Amino Acids
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