By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology is the subject of a report. According to news reporting originating in Tehran, Iran, by NewsRx journalists, research stated, "Here we introduce novel optical properties and accurate sensitivity of Quantum dot (QD)-based detection system for tracking the breast cancer marker, HER2. QD525 was used to detect HER2 using home-made HER2-specific monoclonal antibodies in fixed and living HER2(+) SKBR-3 cell line and breast cancer tissues."
The news reporters obtained a quote from the research from Islamic Azad University, "Additionally, we compared fluorescence intensity (FI), photostability and staining index (SI) of QD525 signals at different exposure times and two excitation wavelengths with those of the conventional organic dye, FITC. Labeling signals of QD525 in both fixed and living breast cancer cells and tissue preparations were found to be significantly higher than those of FITC at 460-495 nm excitation wavelengths. Interestingly, when excited at 330-385 nm, the superiority of QD525 was more highlighted with at least 4-5 fold higher FI and SI compared to FITC. Moreover, QDs exhibited exceptional photostability during continuous illumination of cancerous cells and tissues, while FITC signal faded very quickly. QDs can be used as sensitive reporters for in situ detection of tumor markers which in turn could be viewed as a novel approach for early detection of cancers."
According to the news reporters, the research concluded: "To take comprehensive advantage of QDs, it is necessary that their optimal excitation wavelength is employed."
For more information on this research see: Accurate sensitivity of quantum dots for detection of HER2 expression in breast cancer cells and tissues. Journal of Fluorescence, 2013;23(2):293-302. Journal of Fluorescence can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Journal of Fluorescence - www.springerlink.com/content/1053-0509/)
Our news correspondents report that additional information may be obtained by contacting A.S. Tabatabaei-Panah, Dept. of Biology, Faculty of Basic Sciences, Islamic Azad University, East Tehran Branch (Ghiamdasht), Tehran, Iran. Additional authors for this research include M. Jeddi-Tehrani, R. Ghods, M.M. Akhondi, N. Mojtabavi, A.R. Mahmoudi, E. Mirzadegan, S. Shojaeian and A.H Zarnani (see also Oncology).
The publisher of the Journal of Fluorescence can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Iran, Asia, Tehran, Oncology, Quantum Dots, Breast Cancer, Nanotechnology, Women's Health, Quantum Physics, Emerging Technologies.
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