By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Drugs and Therapies are presented in a new report. According to news reporting originating from Nakorn Panom, Thailand, by NewsRx correspondents, research stated, "The aim of this study was to prepare electrospun chitosan-based nanofiber mats and to incorporate the fruit hull of Garcinia mangostana (GM) extracts into the mats. Chitosan-ethylenediaminetetraacetic acid/polyvinyl alcohol (CS-EDTA/PVA) was selected as the polymers."
Our news editors obtained a quote from the research from Silpakorn University, "The GM extracts with 1, 2 and 3 wt% ?-mangostin were incorporated into the CS-EDTA/PVA solution and electrospun to obtain nanofibers. The morphology and diameters of the mats were analyzed using scanning electron microscopy (SEM). The mechanical and swelling properties were investigated. The amount of GM extracts was determined using high-performance liquid chromatography (HPLC). The antioxidative activity, antibacterial activity, extract release and stability of the mats were evaluated. In vivo wound healing tests were also performed in Wistar rats. The results indicated that the diameters of the fibers were on the nanoscale and that no crystals of the extract were observed in the mats at any concentration. The mats provided suitable tensile strength and swelling properties. All of the mats exhibited antioxidant and antibacterial activity. During the wound healing test, the mats accelerated the rate of healing when compared to the control (gauze-covered). The mats maintained 90% of their content of ?-mangostin for 3 months."
According to the news editors, the research concluded: "The chitosan-based nanofiber mats loaded with GM extracts were successfully prepared using the electrospinning method. These nanofiber mats loaded with GM extracts may provide a good alternative for accelerating wound healing."
For more information on this research see: Electrospun chitosan-based nanofiber mats loaded with Garcinia mangostana extracts. International Journal of Pharmaceutics, 2013;452(1-2):333-43. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
The news editors report that additional information may be obtained by contacting N. Charernsriwilaiwat, Pharmaceutical Development of Green Innovations Group (PDGIG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand. Additional authors for this research include T. Rojanarata, T. Ngawhirunpat, M. Sukma and P. Opanasopit (see also Drugs and Therapies).
Keywords for this news article include: Asia, Thailand, Nakorn Panom, Drugs and Therapies.
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