By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Silicon. According to news originating from Dallas, Texas, by NewsRx correspondents, research stated, "Influenza A viruses (IAVs) cause recurrent epidemics in humans, with serious threat of lethal worldwide pandemics. The occurrence of antiviral-resistant virus strains and the emergence of highly pathogenic influenza viruses have triggered an urgent need to develop new anti-IAV treatments."
Our news journalists obtained a quote from the research from the University of Texas Southwestern, "One compound found to inhibit IAV, and other virus infections, is saliphenylhalamide (SaliPhe). SaliPhe targets host vacuolar-ATPase and inhibits acidification of endosomes, a process needed for productive virus infection. The major obstacle for the further development of SaliPhe as antiviral drug has been its poor solubility. Here, we investigated the possibility to increase SaliPhe solubility by loading the compound in thermally hydrocarbonized porous silicon (THCPSi) nanoparticles. SaliPhe-loaded nanoparticles were further investigated for the ability to inhibit influenza A infection in human retinal pigment epithelium and Madin-Darby canine kidney cells, and we show that upon release from THCPSI, SaliPhe inhibited IAV Infection in vitro and reduced the amount of progeny virus in IAV-infected cells."
According to the news editors, the research concluded: "Overall, the PSi-based nanosystem exhibited increased dissolution of the investigated anti-IAV drug SaliPhe and displayed excellent in vitro stability, low cytotoxicity, and remarkable reduction of viral load in the absence of organic solvents:This proof-of-principle study indicates that PSi nanoparticles could be used for efficient delivery of antivirals to infected cells."
For more information on this research see: Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles. ACS Nano, 2013;7(8):6884-6893. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
The news correspondents report that additional information may be obtained from L.M. Bimbo, Univ Texas SW Med Center Dallas, Dept. of Biochem, Dallas, TX 75390, United States. Additional authors for this research include O.V. Denisova, E. Makila, M. Kaasalainen, J.K. De Brabander, J. Hirvonen, J. Salonen, L. Kakkola, D. Kainov and H.A. Santos (see also Silicon).
Keywords for this news article include: Texas, Dallas, Viruses, Virology, Nanoparticle, United States, Nanotechnology, Porous Silicon, Emerging Technologies, North and Central America
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