By a News Reporter-Staff News Editor at Life Science Weekly -- New research on DNA Research is the subject of a report. According to news reporting originating from Karlsruhe, Germany, by NewsRx correspondents, research stated, "The DNA base substitute approach by the (S)-3-amino-1,2-propanediol linker allows placing two fluorophores in a precise way inside a given DNA framework. The double helical architecture around the fluorophores, especially the DNA-induced twist, is crucial for the desired photophysical interactions."
Our news editors obtained a quote from the research from the Karlsruhe Institute of Technology, "Excitonic, excimer, and energy transfer interactions yield fluorescent DNA and RNA probes with dual emission color readout. Especially, our DNA and RNA 'traffic light' that combines the green emission of TO with the red emission of TR represents an important tool for molecular imaging and can be applied as aptasensors and as probes to monitor the siRNA delivery into cells. The concept can be extended to the synthetically easier to access postsynthetic 2'-modifications and the NIR range."
According to the news editors, the research concluded: "Thereby, the pool of tailor-made fluorescent nucleic acid conjugates can be extended."
For more information on this research see: DNA and RNA "Traffic Lights"Synthetic Wavelength-Shifting Fluorescent Probes Based on Nucleic Acid Base Substitutes for Molecular Imaging. Journal of Organic Chemistry, 2013;78(15):7373-7379. Journal of Organic Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Organic Chemistry - www.pubs.acs.org/journal/joceah)
The news editors report that additional information may be obtained by contacting C. Holzhauser, Karlsruhe Inst Technol, Inst Organ Chem, D-76131 Karlsruhe, Germany (see also DNA Research).
Keywords for this news article include: Europe, Germany, Karlsruhe, DNA Research, Nanotechnology, Molecular Imaging, Emerging Technologies
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