By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Germ Cells are presented in a new report. According to news reporting originating in Ottawa, Canada, by NewsRx journalists, research stated, "Inhalation of particles has been shown to induce mutations in the male germline in mice following both prenatal and adult exposures in several experiments. In contrast, the effects of particles on female germ cell mutagenesis are not well established."
The news reporters obtained a quote from the research from Health Canada, "Germline mutations are induced during active cell division, which occurs during fetal development in females. We investigated the effects of prenatal exposure to carbon black nanoparticles (CB) on induction of mutations in the female mouse germline during fetal development, spanning the critical developmental stages of oogenesis. Pregnant C57BL/6J mice were exposed four times during gestation by intratracheal instillation of 67 mu g/animal of nanosized carbon black Printex90 or vehicle (gestation days 7, 10, 15 and 18). Female offspring were raised to maturity and mated with unexposed CBA males. Expanded simple tandem repeat (ESTR) germline mutation rates in the resulting F2 generation were determined from full pedigrees (mother, father, offspring) of F1 female mice (178 CB-exposed and 258 control F2 offspring)."
According to the news reporters, the research concluded: "ESTR mutation rates in CB-exposed F2 female offspring were not statistically different from those of F2 female control offspring."
For more information on this research see: In utero exposure to nanosized carbon black (Printex90) does not induce tandem repeat mutations in female murine germ cells. Reproductive Toxicology, 2013;41():45-48. Reproductive Toxicology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Reproductive Toxicology - www.elsevier.com/wps/product/cws_home/525489)
Our news correspondents report that additional information may be obtained by contacting A.M.Z. Boisen, Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0K9, Canada. Additional authors for this research include T. Shipley, P. Jackson, H. Wallin, C. Nellemann, U. Vogel, C.L. Yauk and K.S. Hougaard (see also Germ Cells).
Keywords for this news article include: Ottawa, Canada, Ontario, Genitalia, Germ Cells, North and Central America
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC