By a News Reporter-Staff News Editor at Cancer Weekly -- Data detailed on Oncology have been presented. According to news reporting originating in Ann Arbor, Michigan, by NewsRx journalists, research stated, "In order to design effective therapies for prostate cancer, a clear understanding of mechanisms that contribute to various components of prostate cancer progression is necessary. Study of metastasis suppressor genes, i.e., genes that can inhibit metastasis, is an important field of study that can lead to identification of therapeutic targets to diminish metastasis."
The news reporters obtained a quote from the research from the University of Michigan, "E-cadherin has been implicated as an important inhibitor of metastasis. Thus, understanding how it is regulated may lead towards defining mechanism of metastasis suppressor activity. Through a series of studies using genetically-modified cells, Pal et al. determined that SAM Pointed Domain ETS transcription Factor (SPDEF) serves as a molecular switch to turn on E-cadherin expression and thus regulate tumor aggressiveness. They determined SPDEF achieved regulation of expression through binding to and regulating the SPDEF promoter."
According to the news reporters, the research concluded: "These findings provide a strong rationale to explore targeting SPDEF for inhibition of prostate cancer metastasis."
For more information on this research see: SPDEF: a molecular switch for E-cadherin expression that promotes prostate cancer metastasis. Asian Journal of Andrology, 2013;15(5):584-585. Asian Journal of Andrology can be contacted at: Acta Pharmacologica Sinica, 294 Tai-Yuan Rd, Shanghai, 200031, Peoples R China. (Nature Publishing Group - www.nature.com/; Asian Journal of Andrology - www.nature.com/aja/)
Our news correspondents report that additional information may be obtained by contacting M. Osisami, University of Michigan, Dept. of Urol, Ann Arbor, MI 48105, United States (see also Oncology).
Keywords for this news article include: Michigan, Genetics, Oncology, Ann Arbor, Cadherins, United States, Glycoproteins, Nanotechnology, Prostate Cancer, Membrane Proteins, Molecular Switches, Prostatic Neoplasms, Emerging Technologies, Cell Adhesion Molecules, North and Central America
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