By a News Reporter-Staff News Editor at Cancer Weekly -- A new study on Apoptosis is now available. According to news reporting out of Atlanta, Georgia, by NewsRx editors, research stated, "Recently, we have shown that targeting the cancer cell nucleus with solid gold nanospheres, using a cancer cell penetrating/pro-apoptotic peptide (RGD) and a nuclear localization sequence peptide (NLS), inhibits cell division, thus leading to apoptosis. In the present work, flow cytometric analysis revealed an increase in cell death, via apoptosis and necrosis, in HSC cells upon treatment with peptide-conjugated hollow gold nanocages, compared to those treated with the peptide-conjugated solid gold nanospheres."
Our news journalists obtained a quote from the research from the School of Chemistry and Biochemistry, "This is consistent with a G0/G1 phase accumulation, S phase depletion, and G2/M phase depletion, as well as reduced ATP levels. Here, we investigate the possible causes for the observed enhanced cell death with the use of confocal microscopy. The fluorescence images of HSC cells treated with gold nanocages indicate the presence of reactive oxygen species, known to cause apoptosis. The formation of reactive oxygen species observed is consistent with a mechanism involving the oxidation of metallic silver on the inner cavity of the nanocage (inherent to the synthesis of the gold nanocages) to silver oxide. This oxidation is confirmed by an observed redshift in the surface plasmon resonance of the gold nanocages in cell culture medium. The silver oxide, a semiconductor known to photochemically generate hydroxyl radicals, a form of reactive oxygen species, is proposed as a mechanism for the enhanced cell death caused by gold nanocages."
According to the news editors, the research concluded: "Thus, the enhanced cell death, via apoptosis and necrosis, observed with peptide-conjugated hollow gold nanocage-treated cells is considered to be a result of the metallic composition (silver remaining on the inner cavity) of the nanocage."
For more information on this research see: Inducing cancer cell death by targeting its nucleus: solid gold nanospheres versus hollow gold nanocages. Bioconjugate Chemistry, 2013;24(6):897-906. (American Chemical Society - www.acs.org; Bioconjugate Chemistry - www.pubs.acs.org/journal/bcches)
Our news journalists report that additional information may be obtained by contacting M.A. Mackey, Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States. Additional authors for this research include F. Saira, M.A. Mahmoud and M.A El-Sayed (see also Apoptosis).
Keywords for this news article include: Cancer, Atlanta, Georgia, Oncology, Peptides, Proteins, Apoptosis, Nanophere, Chalcogens, Nanosphere, Proteomics, United States, Free Radicals, Nanotechnology, Oxygen Compounds, Emerging Technologies, Reactive Oxygen Species, North and Central America.
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