Now doctoral students
"Until now, when scientists have tried to engineer cardiac tissue, they've used straight fibers to support the contracting cells," says Dr. Dvir. "However, these fibers prevent the contraction of the engineered tissue. What we did was mimic the spring-like fibers that promote contraction and relaxation of the heart muscle. We found that by growing tissues on these fibers, we got more functional tissues."
Springing into action
Cardiac tissue is engineered by allowing cells taken from the hearts of patients or animals to grow on a three-dimensional scaffold, which replaces the extracellular matrix, a collagen grid that naturally supports the cells in the heart. Over time, the cells come together to form a tissue that generates its own electrical impulses and expands and contracts spontaneously. The tissue can then be surgically implanted to replace damaged tissue and improve heart function in patients.
More recently, the researchers identified spiral-shaped collagen fibers in the extracellular matrix of rat hearts. Seeing the potential for an advance, they set out to recreate them for the first time. After fabricating the spring-like fibers using advanced techniques, they subjected them to a variety of tests.
As the researchers predicted, the spring-like fibers showed better mechanical properties than straight fibers, with especially improved elasticity. And compared to tissue engineered with straight fibers, the tissue engineered with spring-like fibers contracted with greater force and less mechanical resistance.
"These properties are very important, because we want to transplant the tissue into the human heart, which expands and contracts constantly," says Fleischer.
Heart disease is responsible for a third of all deaths in
But additional research is needed first. The researchers say the processes for fabricating the fibers and assembling them into a scaffold need to be refined. Most importantly, they say, the ability of the tissue to improve heart function after a heart attack needs to be tested in humans - something they plan to do in pre-clinical and then clinical trials.
Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Cardiology, Heart Attack, Bioengineering, Extracellular Space, Extracellular Matrix, Regenerative Medicine, Clinical Trials and Studies, American Friends of
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC
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