Patent number 8541378 is assigned to
The following quote was obtained by the news editors from the background information supplied by the inventors: "The present invention relates to recombinant albumins fused with poly-cysteine peptide and methods for preparing the same.
"The usability of albumin, as an effective drug in vivo, has been widely known. In particular, in relation to such disease as cancer and rheumatoid arthritis, albumin has been well recognized in its functions as a multi-drug deliverer because of its capability and easiness in improving physical and chemical characteristics such as high accumulation in a target tissue, low invasiveness in a normal tissue, low toxicity, easiness in conjugation with variety of drugs, drug-release in a target tissue, advantageous bio-degradation time, solubility of the fused drug, etc.
"In cancer tissues, albumin is preferably metabolized to produce nitrogen and energy. In angiogenetic blood vessels of cancer tissues, EPR effect (enhanced permeability and retention effect) is observed, that is albumin is accumulated selectively in cancer tissues owing to the increased permeability. Abnormality of lymphatic system in cancer tissues accelerates the accumulation of albumin in cancer tissues. So, drug delivery by albumin is an important target of new drug development, which draws our attention world widely.
"Chemotherapy, one of the conventional methods treating cancer, is limited in clinical application because of biophysicochemical properties of a drug used. That is, if it is a hydrophobic drug insoluble in water, a drug deliverer has to be prepared with an organic solvent such as polyethoxylated castor oil (CrEL) or polysorbate 80. In that case, not only the drug itself but also the drug deliverer can cause toxicity, which can cause hypersensitivity and other serious neuronal disease. Therefore, an additional medical treatment is required to control such toxicity. That is, when a drug deliverer depends on such organic solvent, there might be a problem of dose-limiting because of toxicity of the drug deliverer. Precisely, dose of a drug for in vivo injection can be limited.
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