By a News Reporter-Staff News Editor at Drug Week -- Current study results on Nanoparticles have been published. According to news originating from Philadelphia, Pennsylvania, by NewsRx correspondents, research stated, "The ability to produce submicron particles of monoclonal antibodies of different sizes and shapes would enhance their application to pulmonary delivery. Although non-ionic surfactants are widely used as stabilizers in protein formulations, we hypothesized that non-ionic surfactants will affect the shape and size of submicron IgG particles manufactured through precipitation."
Our news journalists obtained a quote from the research from Thomas Jefferson University, "Submicron particles of IgG1 were produced by a precipitation process which explores the fact that proteins have minimum solubility but maximum precipitation at the isoelectric point. Non-ionic surfactants were used for size and shape control, and as stabilizing agents. Aerosol performance of the antibody nanoparticles was assessed using Andersen Cascade Impactor. SpinhalerŪ and HandihalerŪ were used as model DPI devices. SEM micrographs revealed that the shape of the submicron particles was altered by varying the type of surfactant added to the precipitating medium. Particle size as measured by dynamic light scattering was also varied based on the type and concentration of the surfactant. The surfactants were able to stabilize the IgG during the precipitation process. Polyhedral, sponge-like, and spherical nanoparticles demonstrated improved aerosolization properties compared to irregularly shaped (>20 ?m) unprocessed particles. Stable antibody submicron particles of different shapes and sizes were prepared."
According to the news editors, the research concluded: "Careful control of the shape of such particles is critical to ensuring optimized lung delivery by dry powder inhalation."
For more information on this research see: Self-associated submicron IgG1 particles for pulmonary delivery: effects of non-ionic surfactants on size, shape, stability, and aerosol performance. Aaps Pharmscitech [electronic Resource], 2013;14(1):200-10. Aaps Pharmscitech [electronic Resource] can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA (see also Nanoparticles).
The news correspondents report that additional information may be obtained from A.R. Srinivasan, Dept. of Pharmaceutical Sciences, School of Pharmacy, Thomas Jefferson University, 130 South 9th Street, Edison Building, Suite 1540, Philadelphia, Pennsylvania 19107, United States.
The publisher's contact information for the journal Aaps Pharmscitech [electronic Resource] is: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Antibodies, Immunology, Philadelphia, Pennsylvania, United States, Blood Proteins, Nanotechnology, Immunoglobulins, Emerging Technologies, North and Central America.
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