By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Analytical Chemistry is now available. According to news reporting out of Chatenay Malabry, France, by NewsRx editors, research stated, "We investigate the preconcentration profiles of a fluorescein and bovine serum albumin derivatized with this fluorescent tag in a microfluidic chip bearing a nanoslit. A new preconcentration method in which a hydrodynamic pressure is added to both electroosmotic and electrophoretic contributions is proposed to monitor the location of the preconcentration frontline."
Our news journalists obtained a quote from the research from the University of Paris, "A simple predictive model of this pressure-assisted electropreconcentration is proposed for the evolution of the flow profile along this micro/nano/microfluidic structure. We show with a small analyte such as fluorescein that the additional hydrostatic pressure mode enables to stabilize the concentration polarization (CP) effect, resulting in better control of the cathodic focusing (CF) peak. For BSA (bovine serum albumin), we exhibit that the variation of the hydrodynamic pressure can have an even more drastic effect on the preconcentration. We show that, depending on this hydrodynamic pressure, the preconcentration can be chosen, either in the cathodic side or in the anodic one. For the first time, we prove here that both anodic focusing (AF) and cathodic focusing (CF) regimes can be reached in the same structures."
According to the news editors, the research concluded: "These results also open new routes for the detection and the quantification of low abundance biomarkers."
For more information on this research see: Pressure-Assisted Selective Preconcentration in a Straight Nanochannel. Analytical Chemistry, 2013;85(16):7948-7956. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)
Our news journalists report that additional information may be obtained by contacting A.C. Louer, University of Paris, CNRS UMR 8612, Fac Pharm, F-92296 Chatenay Malabry, France. Additional authors for this research include A. Plecis, A. Pallandre, J.C. Galas, A. Estevez-Torres and A.M. Haghiri-Gosnet (see also Analytical Chemistry).
Keywords for this news article include: France, Europe, Chatenay Malabry, Analytical Chemistry
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