By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Immunology. According to news reporting from Yangzhou, People's Republic of China, by NewsRx journalists, research stated, "Rhodamine B (RhB)-labeled PLA nanoparticles were prepared through surface grafting copolymerization of glycidyl methacrylate (GMA) onto PLA nanoparticles during the emulsion/evaporation process. RhB firstly interacts with sodium dodecyl sulfate (SDS) through electrostatic interaction to form hydrophobic complex (SDS-RhB)."
The news correspondents obtained a quote from the research from Yangzhou University, "Due to the high-affinity of SDS-RhB with GMA, hydrophilic RhB can be successfully combined into PLA nanoparticles. The internalization of RhB-labeled PLA nanoparticles by macrophages was investigated with fluorescence microscope technology. The effects of the PLA nanoparticle surface nature and size on the internalization were investigated. The results indicate that the PLA particles smaller than 200 nm can avoid the uptake of phagocytosis."
According to the news reporters, the research concluded: "The bigger PLA particles (300 nm) with polyethylene glycol (PEG) surface showed less internalization by macrophage compared with those with poly(ethylene oxide-propylene oxide) copolymer (F127) or poly(vinyl alcohol) (PVA) surface."
For more information on this research see: The internalization of fluorescence-labeled PLA nanoparticles by macrophages. International Journal of Pharmaceutics, 2013;453(2):506-513. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news journalists report that additional information may be obtained by contacting F.J. Li, Yangzhou University, Coll Chem & Chem Engn, Yangzhou 225002, People's Republic of China. Additional authors for this research include A.P. Zhu, X.L. Song, L.J. Ji and J. Wang (see also Immunology).
Keywords for this news article include: Asia, Yangzhou, Immunology, Macrophages, Nanoparticle, Nanotechnology, Emerging Technologies, People's Republic of China, Mononuclear Phagocyte System
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