By a News Reporter-Staff News Editor at Drug Week -- A new study on Epithelial Cells is now available. According to news reporting from Shanghai, People's Republic of China, by NewsRx journalists, research stated, "The purpose of this study was to elucidate the effect and possible mechanism of bile salts on the intestinal absorption of lipophilic drug loaded lipid nanocarriers in rats. Effects of sodium cholate (SC) on the characteristics, intestinal absorption, cellular uptake in Caco-2 cell monolayers and intestinal lymphatic transport of candesartan cilexetil loaded lipid nanocarriers (CLN) were investigated to clarify the possible mechanism."
The news correspondents obtained a quote from the research from the Chinese Academy of Sciences, "The intestinal absorption of candesartan from CLN was evidently improved over 16-fold compared with free drug suspension, and further significantly enhanced 1.79-fold after the addition of SC. The cellular uptake of CLN in Caco-2 cell monolayers at 37?C and its colocalization with endoplasmic reticulum were obviously increased in the presence of SC. Moreover, the intestinal lymphatic transport of CLN was obviously enhanced by SC. These results implicated that bile salts could improve the cellular uptake of CLN in Caco-2 cell monolayers via the active processes and promote the intestinal absorption of CLN through the intestinal lymphatic pathway."
According to the news reporters, the research concluded: "Therefore, bile salts could be an important physiological factor affecting the intestinal absorption of lipophilic drugs loaded lipid nanocarriers."
For more information on this research see: Bile salts enhance the intestinal absorption of lipophilic drug loaded lipid nanocarriers: mechanism and effect in rats. International Journal of Pharmaceutics, 2013;452(1-2):374-81. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news journalists report that additional information may be obtained by contacting Z. Zhang, Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Taiwan. Additional authors for this research include F. Gao, S. Jiang, L. Chen, Z. Liu, H. Yu and Y. Li (see also Epithelial Cells).
Keywords for this news article include: Asia, Shanghai, Caco 2 Cells, Nanocarriers, Nanotechnology, Epithelial Cells, Emerging Technologies, People's Republic of China.
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