By a News Reporter-Staff News Editor at Drug Week -- Research findings on Sulfides are discussed in a new report. According to news reporting originating from London, United Kingdom, by NewsRx correspondents, research stated, "Establishing structure-activity relationships is vital if the efficacy of non-viral vectors is to match that of their viral counter-parts. Recently, we reported on the ability of a series of small molecule, cyclic polyamine disulfides to condense and cage plasmid DNA (pDNA) by a process of thermodynamically controlled templated polymerization, leading to a series of corresponding pDNA-polyplex nanoparticles able to mediate high levels of transfection with no associated cytotoxicities."
Our news editors obtained a quote from the research from King's College, "The leading cyclic polyamine disulfide was shown to be the spermine tetra-amine disulfide (TetraN-3,4,3). Herein we report on the significantly more challenging syntheses of cyclic disulfides with longer polyamine motifs. Two new cyclic polyamine disulfides, based on hexa-and octa-amine inserts, were prepared and their transfection efficacies and cytotoxicities compared with our previously reported cyclic tri- and tetra-amine disulfides. The new cyclic hexa-and octa-amine disulfides prove more effective at transfection in vitro, especially of lung epithelial A549 cell line. By contrast, our original cyclic tetra-amine disulfide remains the most efficient agent for the transfection of lung epithelial cells in vivo following intra-nasal administration. Hypothetical mechanistic reasons are presented to explain this outcome."
According to the news editors, the research concluded: "Our data in toto support the concept of shorter cyclic polyamine disulfides as preferred agents for polycation-mediated controlled condensation and functional delivery of pDNA to lung epithelial cells in vivo."
For more information on this research see: Examination of the effect of increasing the number of intra-disulfide amino functional groups on the performance of small molecule cyclic polyamine disulfide vectors. Journal of Controlled Release, 2013;171(1):81-90. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
The news editors report that additional information may be obtained by contacting C.R. Drake, Kings Coll London, Inst Pharmaceut Sci, London SE1 9NH, United Kingdom. Additional authors for this research include A. Aissaoui, O. Argyros, M. Thanou, J.H.G. Steinke and A.D. Miller (see also Sulfides).
Keywords for this news article include: Ions, London, Europe, Disulfides, Polyamines, Electrolytes, United Kingdom, Inorganic Chemicals
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