By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Butyrophenones. According to news reporting from Tehran, Iran, by NewsRx journalists, research stated, "In this study an extraction procedure using molecular imprinted polymer nanoparticles for the determination of haloperidol in biological samples is proposed. The haloperidol imprinted polymer nanoparticles were synthesized successfully by precipitation polymerization in a flask containing haloperidol as a template, ethyleneglycoldimethacrylate as a crosslinking agent, methacrylic acid as a functional monomer, and 2,2'-azobisisobutyronitrile as an initiator."
The news correspondents obtained a quote from the research from Shahid-Beheshti University, "The leached and unleached polymer nanoparticles have been characterized by infrared spectroscopy and scanning electron microscopy. The effect of different variables such as the pH of solution, uptake and elution time, type, and the least amount of eluent for elution of haloperidol from polymer was evaluated. Extraction efficiencies more than 97% were obtained by elution of the polymer with 1.5 mL of methanol-acetic acid-trifluoroacetic acid 79.9:20:0.1. Under optimal conditions maximum adsorption capacity was obtained 153.84 mg g(-1). The detection limit of the proposed procedure was between 0.2 and 0.35 mu g L-1."
According to the news reporters, the research concluded: "Finally this method was applied to the determination of haloperidol in plasma and urine samples and satisfactory results were achieved (RSD
For more information on this research see: Determination of haloperidol in biological samples using molecular imprinted polymer nanoparticles followed by HPLC-DAD detection. International Journal of Pharmaceutics, 2013;453(2):601-609. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news journalists report that additional information may be obtained by contacting H. Ebrahimzadeh, Shahid Beheshti Univ, Dept. of Chem, GC, Tehran, Iran. Additional authors for this research include Z. Dehghani, A.A. Asgharinezhad, N. Shekari and K. Molaei (see also Butyrophenones).
Keywords for this news article include: Iran, Asia, Tehran, Haloperidol, Nanoparticle, Butyrophenones, Nanotechnology, Emerging Technologies
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