By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Drugs and Therapies are presented in a new report. According to news reporting originating from Nagoya, Japan, by NewsRx correspondents, research stated, "We attempted to prepare sustained release fine particles using a two-step mechanical powder processing method; particle-shape modification and dry particle coating. First, particle shape of bulk drug was modified by mechanical treatment to yield drug crystals suitable for the coating process. Drug crystals became. more rounded with increasing rotation speed, which demonstrates that powerful mechanical stress yields spherical drug crystals with narrow size distribution."
Our news editors obtained a quote from the research from Meijo University, "This process is the result of destruction, granulation and refinement of drug crystals. Second, the modified drug particles and polymer coating powder were mechanically treated to prepare composite particles. Polymer nanoparticle agglomerate obtained by drying poly(meth)acrylate aqueous dispersion was used as a coating powder. The porous nanoparticle agglomerate has superior coating performance, because it is completely deagglomerated under mechanical stress to form fine fragments that act as guest particles. As a result, spherical drug crystals treated with porous agglomerate were effectively coated by poly(meth)acrylate powder, showing sustained release after curing."
According to the news editors, the research concluded: "From these findings, particle-shape modification of drug crystals and dry particle coating with nanoparticle agglomerate using a mechanical powder processor is expected as an innovative technique for preparing controlled-release coated particles having high drug content and size smaller than 100 mu m."
For more information on this research see: Design of sustained release fine particles using two-step mechanical powder processing: Particle shape modification of drug crystals and dry particle coating with polymer nanoparticle agglomerate. International Journal of Pharmaceutics, 2013;453(2):523-532. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
The news editors report that additional information may be obtained by contacting K. Kondo, Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan. Additional authors for this research include N. Ito, T. Niwa and K. Danjo (see also Drugs and Therapies).
Keywords for this news article include: Asia, Japan, Nagoya, Drugs and Therapies
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