Our news editors obtained a quote from the research, "Their modular structure makes it easy to re-engineer them for specific purposes. Short of undergoing a trial and error process, these experiments, as well as others, need to rely on an understanding of the specific determinants of the antibody binding mode. In this article, we present a method to identify, on the basis of the antibody sequence alone, which residues of an antibody directly interact with its cognate antigen. The method, based on the random forest automatic learning techniques, reaches a recall and specificity as high as 80% and is implemented as a free and easy-to-use server, named prediction of Antibody Contacts. We believe that it can be of great help in re-design experiments as well as a guide for molecular docking experiments."
According to the news editors, the research concluded: "The results that we obtained also allowed us to dissect which features of the antibody sequence contribute most to the involvement of specific residues in binding to the antigen."
For more information on this research see: Prediction of site-specific interactions in antibody-antigen complexes: the proABC method and server.
The news editors report that additional information may be obtained by contacting
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Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC
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