By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Nanoparticles. According to news reporting originating from Kyunggi Do, South Korea, by NewsRx correspondents, research stated, "We report a nanoparticle-based probe that can be used for a 'turn-on' theragnostic agent for simultaneous Raman imaging/diagnosis and photothermal therapy. The agent consists of a 10 nm spherical gold nanoparticle (NP) with pH-responsive ligands and Raman probes on the surface."
Our news editors obtained a quote from the research from the Samsung Advanced Institute of Technology, "They are engineered to exhibit the surface with both positive and negative charges upon mildly acidic conditions, which subsequently results in rapid aggregations of the gold NPs. This aggregation simultaneously provides hot spots for the SERS probe with the enhancement factor reaching 1.3 x 10(4) and shifts the absorption to far-red and near-infrared (which is optimal for deep tissue penetration) by the coupled plasmon resonances; this shift was successfully exploited for low-threshold photothermal therapy. The theragnostic gold NPs are cancer-specific because they aggregate rapidly and accumulate selectively in cancerous cells. As the result, both Raman imaging and photothermal efficacy were turned on under a cancerous local environment."
According to the news editors, the research concluded: "In addition, the relatively small hydrodynamic size can have the potential for better access to targeted delivery in vivo and facilitated excretion after therapy."
For more information on this research see: Theragnostic pH-Sensitive Gold Nanoparticles for the Selective Surface Enhanced Raman Scattering and Photothernnal Cancer Therapy. Analytical Chemistry, 2013;85(16):7674-7681. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)
The news editors report that additional information may be obtained by contacting S. Jung, Samsung Elect, Frontier Res Lab, Samsung Adv Inst Technol, Yongin 446712, Kyunggi Do, South Korea. Additional authors for this research include J. Nam, S. Hwang, J. Park, J. Hur, K. Im, N. Park and S. Kim (see also Nanoparticles).
Keywords for this news article include: Asia, Cancer, Therapy, Oncology, Kyunggi Do, South Korea, Nanotechnology, Gold Nanoparticles, Emerging Technologies
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