By a News Reporter-Staff News Editor at Journal of Physics Research -- Researchers detail new data in Silicon. According to news reporting out of Seoul, South Korea, by VerticalNews editors, research stated, "Silicon nanocrystals can provide the outstanding imaging capabilities of toxic heavy-metal-based quantum dots without employing heavy metals and have potential for rapid progression to the clinic. Understanding the toxicity of silicon quantum dots (SiQDs) is essential to realizing this potential."
Our news journalists obtained a quote from the research from Korea University, "However, existing studies of SiQD biocompatibility are limited, with no systematic progression from small-animal to large-animal studies that are more clinically relevant. Here, we test the response of both mice and monkeys to high intravenous doses of a nanoconstruct created using only SiQDs and FDA-approved materials. We show that (1) neither mice nor monkeys show overt signs of toxicity reflected in their behavior, body mass, or blood chemistry, even at a dose of 200 mg/kg. (2) This formulation did not biodegrade as expected. Elevated levels of silicon were present in the liver and spleen of mice three months post-treatment. (3) Histopathology three months after treatment showed adverse effects of the nanoformulation in the livers of mice, but showed no such effects in monkeys."
According to the news editors, the research concluded: "This investigation reveals that the systemic reactions of the two animal models may have some differences and there are no signs of toxicity clearly attributable to silicon quantum dots."
For more information on this research see: Assessing Clinical Prospects of Silicon Quantum Dots: Studies in Mice and Monkeys. ACS Nano, 2013;7(8):7303-7310. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news journalists report that additional information may be obtained by contacting J.W. Liu, Korea University, Dept. of Chem, Seoul 136701, South Korea. Additional authors for this research include F. Erogbogbo, K.T. Yong, L. Ye, J. Liu, R. Hu, H.Y. Chen, Y.Z. Hu, Y. Yang, J.H. Yang, I. Roy, N.A. Karker, M.T. Swihart and P.N. Prasad.
Keywords for this news article include: Asia, Seoul, Silicon, Treatment, South Korea, Quantum Dots, Nanotechnology, Quantum Physics, Emerging Technologies
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