By a News Reporter-Staff News Editor at Drug Week -- Current study results on Anions have been published. According to news reporting out of Seoul, South Korea, by NewsRx editors, research stated, "Surface-modified solid lipid nanoparticles (SLNs) containing retinyl palmitate (Rpal) were prepared by the hot-melt method using Gelucire 50/13(®) and Precirol ATO5(®). Dicetyl phosphate (DCP) was added to negatively charge the surfaces of the SLNs and thereby enhance the skin distribution properties of Rpal."
Our news journalists obtained a quote from the research from Chung Ang University, "In vitro skin permeation and in vivo anti-aging studies were performed using SLNs dispersed in a hydrogel. The SLNs were under 100 nm in size with an even polydispersity index (PDI), and the high absolute zeta-potential value was sufficient to maintain the colloidal stability of the SLNs. DCP-modified negative SLNs (DCPmod-SLNs) enhanced the skin distribution of Rpal 4.8-fold and delivered Rpal to a greater depth than did neutral SLNs. The in vivo anti-wrinkle effect of the DCPmod-SLN formulation was Rpal dose-dependent. However, the anti-wrinkle effects of the DCPmod-SLN formulations were significantly different from that of the negative control and effectively prevented the reduction of elastin and superoxide dismutase by UV irradiation."
According to the news editors, the research concluded: "The DCPmod-SLN system presented is a good candidate for topical Rpal delivery."
For more information on this research see: A retinyl palmitate-loaded solid lipid nanoparticle system: effect of surface modification with dicetyl phosphate on skin permeation in vitro and anti-wrinkle effect in vivo. International Journal of Pharmaceutics, 2013;452(1-2):311-20. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news journalists report that additional information may be obtained by contacting H.S. Jeon, College of Pharmacy, Chung-Ang University, 221 Heuksuk-dong, Dongjak-gu, Seoul 156-756, South Korea. Additional authors for this research include J.E. Seo, M.S. Kim, M.H. Kang, D.H. Oh, S.O. Jeon, Seong Hoon Jeong., Y.W. Choi and S. Lee (see also Anions).
Keywords for this news article include: Asia, Seoul, Anions, Phosphates, South Korea, Phosphoric Acids.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC