-- The group is focused on developing sensitive biosensors, and less expensive optical systems, with the aim of improving the performance of LOC devices
Ostendum's chip has at least four independent sensing channels, one of which is used as the reference channel, while the other three constitute the measurement channels. As the latter three can be used to perform the simultaneous detection of three different analytes, it confers the device multiplexing capabilities. Using Ostendum's technology, one can analyze most complex samples such as full blood or whole milk.
The company has constructed a novel method of measurement, wherein one analyte or class of analytes is detected selectively. It involves the pre-coating of each measurement channel with a unique receptor layer. The receptor, typically an antibody, can specifically bind to one class of micro-organisms or biomolecules, whereas the antigen is specifically bound at the measurement channel. This feature distinguishes the product, enabling the user to pre-coat the LOC system with the desired receptors or use pre-coated disposable LOC systems provided by Ostendum.
"By confining the samples containing the test fluid to the microfluidic inlet of the LOC system, the device offers continuous flow, enabling the monitoring of samples in-line and in real time," said
In addition to multiple applications in human healthcare, Ostendum's technology platform is applied in veterinary and plant health, food and beverage, environment and security monitoring. Similarly, LOC devices can be utilized for onsite drinking and waste water analysis, untreated (raw) milk, beverages and food sampling, among many others.
Ostendum's LOC nanodevice will find wide application in early disease diagnostics, especially for cancer and heart diseases. Some of its future applications could include food analysis, e.g. species-specific (Halal) tests, safety, environmental monitoring and R&D pharma.
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