Our news editors obtained a quote from the research from Monell Chemical Senses Center, "However, the identities of the VOCs that discriminate melanoma from normal skin were either unknown or likely derived from exogenous sources. We employed solid-phase micro-extraction, GC-MS and single-stranded DNA-coated nanotube (DNACNT) sensors to examine VOCs from melanoma and normal melanocytes. GC-MS revealed dozens of VOCs, but further analyses focused on compounds most likely of endogenous origin. Several compounds differed between cancer and normal cells, e.g., isoamyl alcohol was higher in melanoma cells than in normal melanocytes but isovaleric acid was lower in melanoma cells. These two compounds share the same precursor, viz., leucine. Melanoma cells produce dimethyldi-and trisulfide, compounds not detected in VOCs from normal melanocytes. Furthermore, analyses of the total volatile metabolome from both melanoma cells and normal melanocytes by DNACNT sensors, coupled with the GC-MS results, demonstrate clear differences between these cell systems."
According to the news editors, the research concluded: "Consequently, monitoring of melanoma VOCs has potential as a useful screening methodology."
For more information on this research see: Volatile biomarkers from human melanoma cells.
The news editors report that additional information may be obtained by contacting
Keywords for this news article include: Melanocytes,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC
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