By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Biomaterials. According to news originating from Bologna, Italy, by NewsRx correspondents, research stated, "Anti-infective biomaterials need to be tailored according to the specific clinical application. All their properties have to be tuned to achieve the best anti-infective performance together with safe biocompatibility and appropriate tissue interactions."
Our news journalists obtained a quote from the research from the University of Bologna, "Innovative technologies are developing new biomaterials and surfaces endowed with anti-infective properties, relying either on antifouling, or bactericidal, or antibiofilm activities. This review aims at thoroughly surveying the numerous classes of antibacterial biomaterials and the underlying strategies behind them. Bacteria repelling and antiadhesive surfaces, materials with intrinsic antibacterial properties, antibacterial coatings, nanostructured materials, and molecules interfering with bacterial biofilm are considered. Among the new strategies, the use of phages or of antisense peptide nucleic acids are discussed, as well as the possibility to modulate the local immune response by active cytokines. Overall, there is a wealth of technical solutions to contrast the establishment of an implant infection. Many of them exhibit a great potential in preclinical models."
According to the news editors, the research concluded: "The lack of well-structured prospective multicenter clinical trials hinders the achievement of conclusive data on the efficacy and comparative performance of anti-infective biomaterials."
For more information on this research see: A review of the biomaterials technologies for infection-resistant surfaces. Biomaterials, 2013;34(34):8533-8554. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news correspondents report that additional information may be obtained from D. Campoccia, University of Bologna, Dept. of Expt Diagnost & Specialty Med, I-40126 Bologna, Italy. Additional authors for this research include L. Montanaro and C.R. Arciola (see also Biomaterials).
Keywords for this news article include: Italy, Europe, Bologna, Technology, Biomaterials, Pre-Trial Research, Clinical Trials and Studies
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