By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Gram-Positive Bacteria are presented in a new report. According to news reporting originating from Seoul, South Korea, by NewsRx correspondents, research stated, "The cellulosome is one of nature's most elegant and elaborate nanomachines and a key biological and biotechnological macromolecule that can be used as a multi-functional protein complex tool. Each protein module in the cellulosome system is potentially useful in an advanced biotechnology application."
Our news editors obtained a quote from the research from Korea University, "The high-affinity interactions between the cohesin and dockerin domains can be used in protein-based biosensors to improve both sensitivity and selectivity. The scaffolding protein includes a carbohydrate-binding module (CBM) that attaches strongly to cellulose substrates and facilitates the purification of proteins fused with the dockerin module through a one-step CBM purification method. Although the surface layer homology (SLH) domain of CbpA is not present in other strains, replacement of the cell surface anchoring domain allows a foreign protein to be displayed on the surface of other strains. The development of a hydrolysis enzyme complex is a useful strategy for consolidated bioprocessing (CBP), enabling microorganisms with biomass hydrolysis activity. Thus, the development of various configurations of multi-functional protein complexes for use as tools in whole-cell biocatalyst systems has drawn considerable attention as an attractive strategy for bioprocess applications."
According to the news editors, the research concluded: "This review provides a detailed summary of the current achievements in Clostridium-derived multi-functional complex development and the impact of these complexes in various areas of biotechnology."
For more information on this research see: Cellulosome-based, Clostridium-derived multi-functional enzyme complexes for advanced biotechnology tool development: Advances and applications. Biotechnology Advances, 2013;31(6):936-944. Biotechnology Advances can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Biotechnology Advances - www.elsevier.com/wps/product/cws_home/525455)
The news editors report that additional information may be obtained by contacting J.E. Hyeon, Korea University, Sch Life Sci & Biotechnol, Seoul 136701, South Korea. Additional authors for this research include S.D. Jeon and S.O. Han (see also Gram-Positive Bacteria).
Keywords for this news article include: Asia, Seoul, South Korea, Clostridium, Cellulosomes, Enzymes and Coenzymes, Gram-Positive Bacteria, Cell Surface Extensions, Gram-Positive Endospore-Forming Rods, Gram-Positive Endospore-Forming Bacteria
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