By a News Reporter-Staff News Editor at Drug Week -- Researchers detail new data in Epithelial Cells. According to news reporting out of Chatenay Malabry, France, by NewsRx editors, research stated, "In vitro cytotoxicity and inflammatory response following exposure to nanoparticles (NPs) made of poly(lactide-co-glycolide) (PLGA) have been investigated on A549 human lung epithelial cells. Three different PLGA NPs (230 nm) were obtained using different stabilizers (polyvinyl alcohol, chitosan, or Pluronic ® F68) to form respectively neutral, positively or negatively charged NPs."
Our news journalists obtained a quote from the research from the French National Institute of Health and Medical Research (INSERM), "Polystyrene NPs were used as polymeric but non-biodegradable NPs, and titanium dioxide (anatase and rutile) as inorganic NPs, for comparison. Cytotoxicity was evaluated through mitochondrial activity as well as membrane integrity (lactate dehydrogenase release, trypan blue exclusion, propidium iodide staining). The cytotoxicity of PLGA-based and polystyrene NPs was lower or equivalent to the one observed after exposure to titanium dioxide NPs. The inflammatory response, evaluated through the release of the IL-6, IL-8, MCP-1, TNF-alpha cytokines, was low for all NPs. However, some differences were observed, especially for negative PLGA NPs that led to a higher inflammatory response, which can be correlated to a higher uptake of these NPs."
According to the news editors, the research concluded: "Taken together, these results show that both coating of PLGA NPs and the nature of the core play a key role in cell response."
For more information on this research see: Toxicity of surface-modified PLGA nanoparticles toward lung alveolar epithelial cells. International Journal of Pharmaceutics, 2013;454(2):686-694. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news journalists report that additional information may be obtained by contacting N. Grabowski, INSERM, UMR Cytokines Chimiokines & Immunopathol 996, F-92296 Chatenay Malabry, France. Additional authors for this research include H. Hillaireau, J. Vergnaud, L.A. Santiago, S. Kerdine-Romer, M. Pallardy, N. Tsapis and E. Fattal (see also Epithelial Cells).
Keywords for this news article include: France, Europe, Chemicals, Chemistry, Nanoparticle, Nanotechnology, Chatenay Malabry, Epithelial Cells, Titanium Dioxide, Emerging Technologies
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